The interstitium is a complex collective of microscopic channels and vessels forming a microvascular system. Its anatomical distribution includes the dermis, vascular adventitia, submucosa of the viscera, bronchi, adipose tissue, and all fascial tissues including musculoskeletal fascia. This is where the inflammation and its proinflammatory mediators get trapped, thus compromising our microvasculature and tissue function and health.

The sensory neurons that perceive pain are known as nociceptors as they detect painful and injurious stimuli. There are four types of nociceptors classified by their velocity of conduction, but it’s the type III and IV that are the most abundant in all fascial expressions. You may have noticed that I use the term fascial expression, and that is because the whole of fascia is far more than myofascia.